Garfield Minus Garfield is a site dedicated to removing Garfield from the Garfield comic strips in order to reveal the existential angst of a certain young Mr. Jon Arbuckle. It is a journey deep into the mind of an isolated young everyman as he fights a losing battle against loneliness and depression in a quiet American suburb.
And then the less successful of the two, and yet still humorous:
(Sidenote: I always thought it was funny that Cathy's famous declaration is Ack and there is a Kathy Acker... and they could not be further from each other: http://en.wikipedia.org/wiki/Kathy_Acker)